What is a common side effect of digoxin therapy in children?

Digoxin is commonly used in pediatric patients to treat various heart conditions, particularly heart failure and certain arrhythmias. A notable side effect of digoxin therapy in children is nausea and vomiting. This is due to its effects on the gastrointestinal system as well as its action on the central nervous system.

When digoxin levels become elevated, whether due to dosage adjustments or changes in a child's hydration status or kidney function, these gastrointestinal symptoms can occur. Nausea can be an early sign of digoxin toxicity, prompting clinicians to evaluate serum digoxin levels and assess for other signs of toxicity, such as changes in heart rhythm.

The other side effects listed—drowsiness, rash and itching, and weight gain—are not as specifically associated with digoxin. While drowsiness might occur with various medications affecting the heart, it is not a characteristic side effect of digoxin, which primarily impacts gastrointestinal and cardiac function. Rash and itching are not commonly linked to digoxin therapy, as it does not typically cause allergic reactions. Weight gain could be seen in cases of fluid retention due to worsening heart failure rather than a direct effect of digoxin itself. Therefore, the association of nausea and vomiting with digoxin therapy is well-established and aligns with what is